Death in hospital following ICU discharge: insights from the LUNG SAFE study, Critical Care

Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073 .

RT education and COVID-19 pneumonia discharge quality Published in Canadian Journal of Respiratory Therapy

Extreme obesity is a strong predictor for in-hospital mortality and the prevalence of long-COVID in severe COVID-19 patients with acute respiratory distress syndrome

Risk factors for hospital mortality in intensive care unit survivors: a retrospective cohort study

Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study, Annals of Intensive Care

European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care

Part 9: Post–Cardiac Arrest Care

Life, Free Full-Text

Frontiers Long-term outcomes of COVID-19 intensive care unit survivors and their family members: a one year follow-up prospective study

New risk stratification models could assist COVID-19 management

Death in hospital following ICU discharge: insights from the LUNG SAFE study. - Abstract - Europe PMC